The NMJ is trough-like to keep ACh from diffusing away, each vesicle has a very high [ACh], and receptors are densely packed in the endplate folds

Vesicles are pre-docked at the active zone to allow maximum exposure to Ca^++, Clathrin coating maximizes the availability of ACh, and post-synaptic receptors are widely distributed across the muscle

The NMJ is trough-like to keep ACh from diffusing away, the EPP is very large, and the EPP lasts very long

AChE can quickly degrade any excess ACh while clathrin coating promotes recycling of vesicles

Vesicles are pre-docked at the active zone to allow maximum exposure to Ca⁺⁺ , many receptors need to bind ACh to produce the EPP, and ACh binds to its receptor for longer than other transmitters