Researchers are investigating
malignant cells that proliferate independently of normal growth constraints.
Detailed molecular profiling identifies multiple alterations affecting
signalling pathways and gene regulation.

Which modification most directly promotes
sustained pro-proliferative signalling in these cancer cells?

Question

Researchers are investigating
malignant cells that proliferate independently of normal growth constraints.
Detailed molecular profiling identifies multiple alterations affecting
signalling pathways and gene regulation.

Which modification most directly promotes
sustained pro-proliferative signalling in these cancer cells?

Answer

Increased
expression of cell surface growth factor receptors driven by gene copy number
gain or enhanced transcription

Answer

Strengthening of
intercellular adhesion through elevated cadherin expression, reinforcing growth
inhibition

Answer

Loss of telomere
maintenance capacity, resulting in early replicative arrest

Answer

Global enhancement of
transcriptional machinery without selective activation of growth ‑ promoting pathways

Crowdly

Researchers are investigating malignant cells that proliferate independently of...

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