A child inherits one mutated copy of
the RB transcriptional corepressor 1 (RB1) gene from a parent but does not
initially develop cancer. Later, a retinal cell acquires a second mutation in
the remaining RB1 allele, and the cell begins to proliferate uncontrollably.

What principle of cancer genetics does
this example best illustrate?

Question

A child inherits one mutated copy of
the RB transcriptional corepressor 1 (RB1) gene from a parent but does not
initially develop cancer. Later, a retinal cell acquires a second mutation in
the remaining RB1 allele, and the cell begins to proliferate uncontrollably.

What principle of cancer genetics does
this example best illustrate?

Accepted Answer

Tumour
formation requires loss of function of both RB1 alleles

Answer

Cancer occurs when a
single RB1 allele becomes activated

Answer

Cancer only develops
when RB1 mutations are inherited from both parents

Answer

RB1 mutations
stimulate DNA synthesis when one allele is present

Crowdly

A child inherits one mutated copy of the RB transcriptional corepressor 1 (RB1)...

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