Weight loss causes a long-term decrease in

leptin, this coincides with increased ghrelin leading to activation of the

NPY/AGRP neurons and inhibition of POMC neurons

Weight

loss causes a long-term decrease in leptin, this coincides with increased

ghrelin leading to elevated food intake but no direct change in energy

expenditure

Weight

loss causes a sustained increase in ghrelin secretion this causes long-term

activation in the NPY/AGRP neurons without any change in POMC activity

After

a meal, the rise in the gut satiety peptides GLP-1, PYY and CCK is attenuated,

this leads to increased hunger that is relayed only via the vagal afferents

from the stomach to the brainstem