Which type of molecular defect can be targeted using siRNA-based therapeutics? (you can select more than one correct answer)

Question

Answer

A loss-of-function mutation resulting in the absence of a specific protein

Answer

All of the alternatives

Answer

A gain-of-function mutation leading to the accumulation of a misfolded protein

Answer

The overexpression of a disease-related gene due to gene amplification

Answer

Trisomy of chromosome 21

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