Trials powered to assess hard clinical end points with regard to oxygen use in this context are lacking. Thus, the efficacy of routine oxygen therapy in patients with myocardial infarction remains highly uncertain.

We therefore conducted a registry-based

randomized 

Therefore, for more than a century, supplemental oxygen has been used routinely in the treatment of patients with suspected acute myocardial infarction and is recommended in clinical guidelines.

Myocardial infarction is caused by a mismatch of oxygen and substrate supply and demand in the myocardium that leads to ischemia and ultimately to cell death.