Both CD28 and CTLA-4 are receptors on T cells that are critical for regulating T cell activity. How does CD28 differ from CTLA-4?

Question

Both CD28 and CTLA-4 are receptors on T cells that are critical for regulating T cell activity.  How does CD28 differ from CTLA-4?

Accepted Answer

CD28 is constitutively expressed on naïve T cells, whereas CTLA-4 is expressed on activated T cells

Answer

CD28 is important for delivering 'signal 1' for T cell activation, and CTLA-4 is important for delivering 'signal 2'

Answer

CD28 binds B7 (CD80 & CD86) with significantly greater affinity than CTLA-4

Answer

Only CD28 binds the B7 costimulatory ligands (CD80 & CD86) expressed on professional antigen-presenting cells

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