Ethylene glycol, the major ingredient in antifreeze, is occasionally consumed by alcoholics as a substitute of true alcohol beverages. In metabolism of ethylene glycol a highly toxic aldehyde is produced, much more toxic than acetaldehyde, produced from ethanol. Ethanol is often administered as a treatment in cases of ethylene glycol poisoning. What is the most likely reason that ethanol is an effective treatment for ethylene glycol poisoning?

Question

Ethylene glycol, the major ingredient in antifreeze, is occasionally consumed by alcoholics as a substitute of true alcohol beverages. In metabolism of ethylene glycol a highly toxic aldehyde is produced, much more toxic than acetaldehyde, produced from ethanol. Ethanol is often administered as a treatment in cases of ethylene glycol poisoning. What is the most likely reason that ethanol is  an effective treatment for ethylene glycol poisoning?

Answer

Ethanol induces another enzyme which effectively metabolize ethylene glycol

Answer

Acetaldehyde, which is produced by the reaction of ADH with ethanol, is of therapeutic value

Answer

Ethanol is an allosteric effector of ADH in addition to being a substrate

Answer

Ethanol combines with a toxic product formed by the reaction of ADH with ethylene glycol and converts it to a harmless product

Answer

Alcohol dehydrogenase (ADH) exhibits a much lower Michaelis constant (Km) for ethanol than for ethylene glycol

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Ethylene glycol, the major ingredient in antifreeze, is occasionally consumed by...

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