Mutations in the gene encoding Patched have been detected in basal cell carcinomas (BCCs) which is a type of skin cancer. The mutations inactivate the Patched protein making it non-functional. Would the inactivation of Patched result in overexpression or under expression of Hedgehog target genes in basal carcinoma cells? Use your knowledge of the Hedgehog signalling pathway to justify your response. (2-3 sentences) (2 marks)