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A Gram‑negative bacterial species acquires mutations that reduce expression of ...
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A Gram‑negative bacterial species acquires mutations that reduce expression of outer‑membrane porins. This decreases susceptibility to β‑lactams and carbapenems, without altering target enzymes or producing β‑lactamases. The mutations also slow nutrient uptake and reduce growth rate in antibiotic‑free environments.
If antibiotic use remains high over time, what
evolutionary outcome is most likely?
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