A
cancer sequencing profile shows that a patient carries a germline pathogenic
variant in a classical tumour suppressor gene, across all normal tissues. In
the tumour sample, the remaining wild‑type allele is absent due to a somatic
loss‑of‑heterozygosity event.

Which
statement BEST reflects how tumour suppressor genes contribute to oncogenesis?

Question

A
cancer sequencing profile shows that a patient carries a germline pathogenic
variant in a classical tumour suppressor gene, across all normal tissues. In
the tumour sample, the remaining wild‑type allele is absent due to a somatic
loss‑of‑heterozygosity event.

Which
statement BEST reflects how tumour suppressor genes contribute to oncogenesis?

Accepted Answer

Inactivation of both alleles of a tumour suppressor is commonly
necessary to promote tumour development

Answer

Tumour
suppressors are generally inactive and become activated only after transformation

Answer

Tumour
suppressors act exclusively by preventing proto‑oncogenes from becoming
oncogenes

Answer

Tumour
suppressors operate only through control of cell‑cycle checkpoints

Crowdly

A cancer sequencing profile shows that a patient carries a germline pathogenic ...

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