During an immune response, B cells can modify the antibodies
they produce without changing antigen specificity. This modification alters how
antibodies interact with other components of the immune system.

Which observation would provide the strongest
evidence that class switch recombination has occurred in a population of B
cells?

Question

During an immune response, B cells can modify the antibodies
they produce without changing antigen specificity. This modification alters how
antibodies interact with other components of the immune system.

Which observation would provide the strongest
evidence that class switch recombination has occurred in a population of B
cells?

Answer

Mutations
accumulate within the antigen-binding region of the antibody

Answer

Progressive
improvement in antibody binding strength is observed over time

Answer

Detection
of IgG and IgA antibodies sharing identical heavy chain CDR sequences

Answer

The
identical antigen specificity is detected in multiple antibody isotypes with
distinct effector functions

Crowdly

During an immune response, B cells can modify the antibodies they produce witho...

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