Long‑lived plasma cells can persist for
years in specialised bone marrow niches, continuing to secrete high‑affinity
antibodies even in the absence of ongoing antigen exposure. Experimental
disruption of stromal cell interactions or cytokines such as APRIL, BAFF and IL‑6
leads to a rapid loss of these plasma cells.

What does this most strongly indicate about the
biology of long‑lived plasma cells?

Question

Long‑lived plasma cells can persist for
years in specialised bone marrow niches, continuing to secrete high‑affinity
antibodies even in the absence of ongoing antigen exposure. Experimental
disruption of stromal cell interactions or cytokines such as APRIL, BAFF and IL‑6
leads to a rapid loss of these plasma cells.

What does this most strongly indicate about the
biology of long‑lived plasma cells?

Accepted Answer

Their
survival depends on extrinsic signals provided by specialised
microenvironmental niches

Answer

They
are intrinsically long‑lived and require only structural attachment for
survival

Answer

They
primarily reflect early immune responses rather than affinity‑matured populations

Answer

They
permanently reside in the tissue where initial B‑cell activation occurred

Crowdly

Long‑lived plasma cells can persist for years in specialised bone marrow niche...

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