it is a toxic substance, it is immediately

detoxified by binding to glutamate or 2-oxoglutarate, or by the formation of

carbamoyl phosphate

a large increase in its level is found in its

insufficient excretion in kidney disease, a slight increase is found in

increased protein breakdown (increased food intake, in acute conditions,

bleeding into the GIT, administration of corticoids, Cushing's syndrome,

intensive training); reduction caused e.g. by reduced synthesis in the liver

when it is damaged, physiologically reduced values ​​in children and in

pregnancy

the concentration of this substance is directly

proportional to the muscle mass in the body, its determination is used to

monitor kidney disease (determination of its clearance)