A. Describe one limitation of the study that you noticed, or a question that you think remains unanswered after reading the paper. (2–4 sentences.)

B. Propose one realistic follow-up experiment that could be done in a lab to address that limitation or question.

• What would you measure (for example, a particular epigenetic mark, gene expression level, or phenotype)?
• How would the result help strengthen or challenge the authors’ conclusions?