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Combinatorial and junctional diversity give us a large immune repertoire. A consequence of this process is:
Every epitope from every pathogen encountered will be recognised by at least one T cell or B cell
Autoreactive cells can be generated and these will cause autoimmune disease
Every MHC:peptide combination can be recognised by a T cell or B cell receptor
Autoreactive cells will be generated and these may cause autoimmune disease
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