A dendritic cell that has phagocytosed a pathogen in a peripheral tissue will upregulate the expression of the chemokine receptor CCR7. What is the purpose of CCR7 expression?

Question

A dendritic cell that has phagocytosed a pathogen in a peripheral tissue will upregulate the expression of the chemokine receptor CCR7.  What is the purpose of CCR7 expression?

Accepted Answer

To allow it to migrate into lymphoid organs

Answer

To allow it to migrate towards the pathogen (following the chemokine gradient) to further sample antigen for presentation on MHC

Answer

To translocate antigen into the cytosol to facilitate cross-presentation

Answer

To engage with the B7 ligand (CD80 & CD86) for co-stimulation

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A dendritic cell that has phagocytosed a pathogen in a peripheral tissue will up...

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