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A 35-year-old male is brought in by ambulance with an overdose of paracetamol. ...

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A 35-year-old male is brought in by ambulance with an overdose of

paracetamol. He was found by neighbours alone in his unit. He had written a

suicide note that says he took 50 tablets of 500mg, dated 3 days ago.

On arrival, he is jaundiced. HR 105, BP 105/90, RR 24, Temp

36.1. He is unable to follow commands and is disorientated to time place and

person.

His pathology findings are:

  • Bilirubin 82umol/L (1-20)
  • ALT 3890 U/L (5-40)
  • AST 7257 U/L (5-30)
  • Alkaline phosphatase 178 U/L (30-110)
  • Creatinine 0.30 mmol/L (0.60-0.11)
  • INR 6.9 (< 1.5)
  • Paracetamol level is 22 mg/L

Paracetamol treatment nomogram

Which

of the following is the most immediate management in the ED?

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