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Shown below (left) is a hydropathy plot for a polytopic integral membrane protei...

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Shown below (left) is a hydropathy plot for a polytopic integral membrane protein.

Also shown (right) are four topology diagrams (A-D) for integral membrane proteins.

Image failed to load: Hydropathy plots

Red arrows indicate the positions at which lysine residues are readily labelled with a chemical reagent added to the extracellular medium.

Which topology diagram is most consistent with the hydropathy plot and lysine labelling pattern shown?

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