Natural killer (NK) cells are well known for their ability to control viral infections and eliminate tumor cells. According to the “licensing” hypothesis, interactions between self-specific MHC I receptors and self-MHC I molecules are essential for NK cell functionality. Notably, both licensed and unlicensed NK cells exist. Which statement is correct?

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Licensed NK cells recognize HLA-DM molecules, since the inhibitory receptor binds to HLA-DM

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The self-specific receptor of NK cells, such as KIR, must interact with self-MHC I molecules from the target cell to be functional; these are known as licensed NK cells

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Generally, NK cells do not possess an activating receptor, which restricts the effectiveness of immunotherapy

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Both licensed and unlicensed NK cells do not recognize MHC I

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NK cells cannot eliminate cancer cells because these cells do not release perforin and granzyme B after activation

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Natural killer (NK) cells are well known for their ability to control viral infe...

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