A naïve T cell requires co-stimulation to be activated by a dendritic cell

A naïve T cell requires signalling through LFA-1 to activate transcription factors necessary for effector functions

A naïve T cell that binds too strongly with peptide:MHC will be deleted as it is potentially self-reactive

A naïve T cell either requires co-stimulation or very high affinity binding between peptide:MHC to be activated by a dendritic cell