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If in the TCR alpha chain gene locus there are 35 V region gene elements, and 45...

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If in the TCR alpha chain gene locus there are 35 V region gene elements, and 45 J region gene elements and in the TCR beta chain gene locus there are 46 V region gene elements, 5 D region gene elements and 11 J region gene elements, how many different TCR combinations can be generated?
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