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Codeine produces analgesia primarily after being metabolised to morphine by the...
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Codeine produces analgesia primarily after being metabolised to morphine by the liver enzyme CYP2D6. Genetic variation can result in differences in the number of functional copies of the CYP2D6 gene, altering enzyme activity.
In a patient who carries an additional functional copy of the CYP2D6 gene, which outcome is MOST LIKELY following standard doses of codeine?
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