A woman carries a pathogenic mutation in her mitochondrial
DNA that places any biological child at high risk of developing a severe,
early-onset mitochondrial disorder. She and her partner seek a reproductive
option that allows them to have a genetically related child while minimising
the risk of disease transmission.

In this context, what is the primary therapeutic purpose of
mitochondrial donation (mitochondrial replacement therapy)?

Question

A woman carries a pathogenic mutation in her mitochondrial
DNA that places any biological child at high risk of developing a severe,
early-onset mitochondrial disorder. She and her partner seek a reproductive
option that allows them to have a genetically related child while minimising
the risk of disease transmission.

In this context, what is the primary therapeutic purpose of
mitochondrial donation (mitochondrial replacement therapy)?

Accepted Answer

To
prevent transmission of pathogenic mitochondria inherited exclusively from the
mother

Answer

To
replace defective mitochondria inherited from either parent with healthy donor
mitochondria

Answer

To
correct nuclear gene variants associated with mitochondrial disease

Answer

To
treat mitochondrial dysfunction in the mother prior to conception

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A woman carries a pathogenic mutation in her mitochondrial DNA that places any ...

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