A couple seeks genetic counselling after their first male child is diagnosed with a neurodevelopmental disorder. Genetic testing reveals a deletion on chromosome 15, and both parents carry this deletion but are asymptomatic. Their second male child, who also carries the same deletion, is completely asymptomatic.
What is the most likely explanation for this inheritance pattern?

Question

A couple seeks genetic counselling after their first male child is diagnosed with a neurodevelopmental disorder. Genetic testing reveals a deletion on chromosome 15, and both parents carry this deletion but are asymptomatic. Their second male child, who also carries the same deletion, is completely asymptomatic. 
 What is the most likely explanation for this inheritance pattern?

Answer

The deletion affects a region subject to genomic imprinting

Answer

The disorder results from mitochondrial inheritance

Answer

The deletion is X-linked and only affects males due to hemizygosity

Answer

The disorder is autosomal dominant with full penetrance

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A couple seeks genetic counselling after their first male child is diagnosed wit...

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