Adiponectin
is considered a beneficial adipokine because it enhances metabolic function.
Which of the following pathways represents the molecular signalling mechanism
of adiponectin in its target tissues?

Question

Accepted Answer

It
binds to AdipoR, recruiting AMPK, promoting GLUT4 translocation and stimulating
beta-oxidation via ACC phosphorylation/inhibition.

Answer

It
directly inhibits insulin receptor substrate 1 (IRS1) to reduce glucose
transport in states of obesity.

Answer

It
is an anti-inflammatory cytokine secreted exclusively by M1 macrophages to downregulate
skeletal muscle GLUT4.

Answer

It
binds to TNF receptors, activating JNK and suppressing downstream PI3K/AKT
signalling to prevent lipid accumulation.

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