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How does the hormone ghrelin influence the homeostatic feeding circuit?

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How does

the hormone ghrelin influence the homeostatic feeding circuit?

It inhibits AgRP/NPY neurons to signal satiety after a meal.

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It binds to receptors on POMC neurons to stimulate the release of α-MSH.

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It decreases the motivation for food seeking by suppressing dopamine release.

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It binds to the GHSR on AgRP/NPY neurons to activate them and increase appetite.

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