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A 65-year-old patient in the ICU develops a bloodstream infection with Acineto...
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A 65-year-old patient in the ICU develops a bloodstream infection with . Laboratory testing shows reduced susceptibility to multiple carbapenems. Further investigation reveals that the isolate carries the gene on a conjugative plasmid and produces a carbapenemase enzyme that hydrolyzes beta-lactam antibiotics. The isolate remains susceptible to colistin.
Which general mechanism most likely explains the reduced carbapenem susceptibility in this strain?
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