Cytokine signals provided by helper T cells influence
antibody isotype production during immune responses. In vitro experiments using
mouse B cells demonstrate that exposure of B cells to IL‑4 biases
class switching toward IgG1 and IgE.

Which mechanism BEST explains how IL‑4 determines this isotype outcome?

Question

Cytokine signals provided by helper T cells influence
antibody isotype production during immune responses. In vitro experiments using
mouse B cells demonstrate that exposure of B cells to IL‑4 biases
class switching toward IgG1 and IgE.

Which mechanism BEST explains how IL‑4 determines this isotype outcome?

Accepted Answer

It
selectively promotes transcription and accessibility of switch regions upstream
of IgG1 and IgE constant region genes

Answer

It
globally enhances AID catalytic activity, with switch-region choice occurring
independently

Answer

It
increases double-strand break formation across all switch regions without specificity

Answer

It
indirectly alters isotype choice by increasing the number of B-cell divisions

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