A researcher is testing an antisense
oligonucleotide (ASO) designed to reduce the expression of a
disease-causing protein. After treatment, the level of the target mRNA decreases significantly , and
as a result, much less of the protein is produced.

Which mechanism most likely explains how the ASO
produced this effect?

Question

A researcher is testing an  antisense
oligonucleotide (ASO)  designed to reduce the expression of a
disease-causing protein. After treatment, the level of the  target mRNA decreases significantly , and
as a result, much less of the protein is produced.

Which mechanism most likely explains how the ASO
produced this effect?

Accepted Answer

The
ASO binds to the target mRNA and recruits  RNase H , which degrades the RNA
strand

Answer

The
ASO forms complexes with cellular proteases that degrade the translated protein

Answer

The
ASO blocks RNA polymerase from binding to the gene promoter

Answer

The
ASO blocks mRNA binding to the ribosome through steric hinderance

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A researcher is testing an antisense oligonucleotide (ASO) designed to reduce...

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