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Mast cells are particularly important in innate immune responses because:

They have a role in adaptive responses as antigen-presenting cells and are targets of the effector components of adaptive responses

They are capable of detecting infectious agents and initiating an acute inflammatory response through direct pathogen killing

Mast cells produce acute phase proteins and induce fever

They are capable of detecting infectious agents and initiating an acute inflammatory response through production of IL-1 beta, IL-6, and IL-8 and IL-3

They are capable of detecting infectious agents and initiating an acute inflammatory response through secretion of mediators (histamine, tryptase, chymase, and carboxypeptidas)

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