increases as the P_O2 increases

increases as the pH decreases

increases when DPG binds to it

increases as the P_CO2 increases

releases ATP in response to low sodium load (tubulo-glomerular feedback)

releases renin in response to low sodium load

is a sensor of Na⁺ concentration in the lumen, independent of GFR

expresses the same transport systems as the thick part of the ascending limb of Henle's loop

contains cells that sense sodium concentration in the lumen and activate the release of renin by the iuxtaglomerular apparatus

contains cells that respond to vasopressin by expressing aquaporins

contains both principal cells involved in regulating sodium reabsorption and intercalated cells involved in proton secretion and bicarbonate synthesis

has a water-permeable epithelium