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IMM2011 - Basic immunology: The body's defence system - S1 2025

IMM2011 - Basic immunology: The body's defence system - S1 2025

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Cross-presentation by dendritic cells; that can occur in response to virally infected skin cells, is when:

The dead infected is held on the surface of the dendritic cell by the MHC class I and MHC class II molecules to present to both CD4 and CD8 T cells

The dendritic cell engulfs the dead cell and transports antigen from the cytoplasm into the MHC class II pathway so both pathways are utilised.

Viral particles from dead cells bind directly to surface MHC class I and MHC class II molecules to activate T cells.

Dead infected cells are engulfed and viral antigens will be transported into the cytoplasm and enter the MHC class I pathway.

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Based on the concept of co-dominance, the number of different MHC class II units (a unit is an alpha and beta chain) expressed on each cell will be:

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When considering the expression of MHC class I molecules in an individual, which statement is correct?

Each individual MHC class I molecule can only present the same set of peptides.

Each set of MHC class I molecules encoded in each chromosome and inherited from each parent will present the same set of peptides.

There may be some overlap in the peptides presented by each MHC class I molecule but they are not identical

Only those from one parent will be expressed.

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The fact that polymorphism in the MHC exists, means that:

Each MHC class I and MHC class II molecule in a particular individual is the same.

There are multiple MHC molecules expressed in each individual.

The structures and peptide binding specificity of MHC molecules changes in response to infecting peptides.

MHC molecules across individuals will not be presenting the same peptides.

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What is the purpose of the structure called CLIP in the MHC class II antigen processing pathway?

To represent cytoplasmic peptides in MHC class II to allow CD4 T cell responses to be generated to cytoplasmic peptides.

To direct the migration of MHC class II from the endoplasmic reticulum to the cell surface.

To prevent peptides within the endoplasmic reticulum from filling the MHC class II cleft

To stop endosomal peptides from binding in the MHC class II cleft

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If you consider a skin cell that has been infected with a virus, which antigen processing pathway will be employed by the cell to present viral peptides?

MHC class I pathway

MHC class II pathway

MHC class I and MHC class II pathways

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Is it possible for a cell to have both the class I and class II antigen processing pathways occurring at the same time?

Yes, some cells can do this but not all cells

Yes but only one pathway at a time, depending on the situation

Yes, and all cells have this capacity.

No, this is not possible

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When thinking about the MHC class II antigen presentation pathway, the antigen that is processed will initially be located:

The extracellular environment of the cell

The cytoplasm of the cell

The endoplasmic reticulum of the cell

The endosomal compartment of the cell

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When thinking about the MHC class I antigen presentation pathway, the antigen that is processed will initially be found in:

The extracellular environment of the cell

The cytoplasm of the cell

The endoplasmic reticulum of the cell

The endosomal compartment of the cell

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For each of the cells listed, indicate if they

express MHC class I and/or MHC class II.

Thymic epithelial cells

Dendritic cells

Red blood cells

Macrophages

Neutrophils

B lymphocytes

Kidney cells

Skin epithelial cells

Liver cells

T lymphocytes

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