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IMM2011 - Basic immunology: The body's defence system - S1 2025

IMM2011 - Basic immunology: The body's defence system - S1 2025

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The innate immune system include a range of non-specific, and broadly specific, effector functions that add a 'layer' of protection. An example is tears in the eye that provide protection due to:

A steady flow of fluid over the eye

An acidic environment

The presence of enzymes

✅

A high concentration of tissue-specific neutrophils

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Name these cells in order from left to right (1 to 4):

Image failed to load

1: Eosinophil, 2: Lymphocyte, 3: Neutrophil, 4: Basophil

1: Neutrophil, 2: Lymphocyte, 3: Eosinophil, 4: Basophil

1: Lymphocyte, 2: Basophil, 3: Neutrophil, 4: Eosinophil

1: Basophil, 2: Lymphocyte, 3: Eosinophil, 4: Neutrophil

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During development in the thymus, a thymocyte will express a TCR. During the selection process, if that TCR binds to MHC and peptide with very high affinity, the cell will:

Secrete IL-7 to stimulate proliferation of neighbouring cells, and then undergo rapid apoptosis

Be removed from the T cell repertoire

Undergo additional VDJ recombination to generate a new receptor

Secrete IL-7 and then undergo rapid proliferation

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In the Tasmanian Devil, MHC diversity is reduced, and this has been linked to the increased transmissibility of the Devil Facial Tumour Disease. The link with MHC diversity is likely associated with:

A lack of MHC expression in the Tasmanian Devils.

The inability to establish MHC restriction.

A reduced ability to present tumour peptides to T cells.

✅

The tumour cells having a reduced MHC diversity.

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Toll-Like Receptors (TLRs) are a family of Pattern Recognition Receptors (PRRs) associated with innate immune responses. Which of the following statements about TLRs is true?

TLRs are part of the NLRP-3 inflammasome

All innate cells express all TLRs

TLRs can respond to both proteins and nucleic acids

✅

TLRs are only found on and in neutrophils (on cell membrane and in endosomes)

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Name these cells in order from left to right (1 to 4):

Image failed to load

1: Eosinophil, 2: Lymphocyte, 3: Neutrophil, 4: Basophil

100%

1: Neutrophil, 2: Lymphocyte, 3: Eosinophil, 4: Basophil

1: Lymphocyte, 2: Basophil, 3: Neutrophil, 4: Eosinophil