Allow for the use of metabolic products as neurotransmitters rather than excreting them

Allow for much greater diversity of signalling

Are more likely to cause highly synchronous activity in linked cells

Transmit information much faster

Are less metabolically demanding

Secondary messenger systems

Calcium entry into the terminal

Vesicle fusion

Protein transport along the axon

Action potential propagation

Is an integral transmembrane protein with 7 trans-membrane segments

Is a membrane-associated protein with 7 trans-membrane segments

Is an ionotropic receptor protein

Is also used in cell-to-cell recognition processes

Is part of the MHC that is used to prevent auto-immune destruction

Docking proteins

Vesicle recycling

Active zones

Vesicles with transmitter

Vesicles with ions

Calcium does not play an important role in the process of neurotransmitter release

Both A and B are true

The use of calcium is more efficient at peptidergic synapses as compared to non-peptidergic synapses

Large amounts of calcium are always found in the axon terminal to allow for continuous release of transmitter

Calcium entry into the axon terminal is regulated by voltage-gated channels which are found in active zones on the terminal membrane

Both involve the use of chemical agents to affect target cells

One is classified as being synaptic and the other classified as being non-synaptic

Both involve the use of synaptic vesicles

One involves only neurons and the other involves neurons and non-neuronal cells

One involves signalling over short distances and the other over long distances

Lower affinity processes in use of Ca⁺⁺

Faster Clathrin-mediated endocytosis

Need for Ca⁺⁺ to move vesicles to docking sites

Fewer vesicles docked at terminal

More inefficient use of Ca⁺⁺ 

SNAP 25

Dynamin

Clathrin

Neurnexin

Neuroligin