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BMS/GNA2042 - Human Genetics - S2 2025

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When analysing a pedigree, which of the following features would fit with an Mitochondrial mode of inheritance?

(Select all that apply)

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Why do we very rarely see Y-linked traits in family pedigrees?

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When analysing a pedigree, which of the following features would fit with an X-linked Dominant mode of inheritance?

(Select all that apply)

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When analysing a pedigree, which of the following features would fit with an Autosomal Dominant mode of inheritance?

(Select all that apply)

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When analysing a pedigree, which of the following features would fit with an Autosomal Recessive mode of inheritance?

(Select all that apply)

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The yellow pea allele (Y) is dominant to the green pea allele (y). The round pea allele (R) is dominant to the wrinkled pea allele (r).

You obtain a Yellow and round pea, and a Yellow and wrinkled pea, grow them into plants and test cross them both. Their genotypes are:

Plant 1: YyRr

Plant 2: Yyrr

You decide to cross Plant 1 with Plant 2.

Without drawing a 4 x 4 punnet square, how might you answer the following questions?

1. What is the chance of a pea from this cross having the genotype YYrr?

2. What is the chance of the pea from this cross being yellow and round?

Hint: The inheritance of the alleles from the 'yellow' gene and the inheritance of alleles from the 'green' gene are independent events. 

Put your thoughts and calculations below.

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You take the F1 from the cross above and interbreed them to

produce an F2. Based on the mode of inheritance of these traits, which

phenotypic ratio would you expect in the F2?

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You identify a polka-dot mutant of Drosophila. You obtain a true breeding polka-dot line and a true breeding wildtype line (no dots)

You perform a reciprocal cross and find:

Female polka-dot x male wildtype: Females wildtype (no dots), males polka-dot

Female wildtype x male polka-dot: All progeny wildtype (no dots)

How would you express the wildtype and mutant alleles, respectively?

Pay attention to the cases of the alleles. 

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 You identify an orange mutant of Drosophila. You obtain a true breeding orange-bodied line and a true breeding wildtype bodied line.

You perform a reciprocal cross and find:

Female orange x male wildtype: All progeny orange bodied

Female wildtype x male orange: All progeny orange bodied

How would you express the wildtype and mutant alleles, respectively? 

Note: pay attention to the case of the letters. 

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Which of the following sex-associated traits are true, and therefore can be used in combination to best determine the sex of Drosophila?

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