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BPS3082 Applied pharmacokinetics, dynamics and product development S2 2025
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Which effect intensity will be achieved by doubling that concentration (i.e. by using a concentration equivalent to 2x EC50)?
Which concentration is required to achieve 50% of the maximal effect intensity?
Which option would you select to compare treatments?
Option 1: “This database is a big mess, let’s just analyze for treated vs. non-treated.”
Option 2: “Marketing is only interested in 400 mg, since 800 mg is too toxic. Let’s do four t-tests, ‘is dose X signifi-cantly different from placebo.”
Option 3: “Why don’t we apply ANOVA to use all data simultaneously for the comparison between doses and placebo.”
Option 4: “Maybe we should treat dose as a continuous variable and plot it vs. effect.”
Option 5: “Some people like to plot AUC vs. dose. Does it really make a difference to plot AUC?”
Option 6: A different form of analysis?