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DEV3011 - Experimental developmental biology and disease modelling - S1 2026

DEV3011 - Experimental developmental biology and disease modelling - S1 2026

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A mouse embryo has a mutation that disrupts specification of the sclerotome. What direct effect might this have?

Abnormal development of the dermis in the skin

Muscle wastage in the trunk and and limbs

Abnormal somite formation

Perturbed bone development

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What is a feature of cadherins? Chose the correct answer below.

They are transmembrane proteins.

They are secreted by one cell and bind to receptors on neighbouring cells.

They mediate contact inhibition.

They bind each other in a heterophilic manner.

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In the chicken embryo,

a researcher has removed the forelimb bud mesenchyme from beneath the AER and

replaced it with non-limb mesenchyme.

Which result might

they expect?

Choose the best option below.

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What is the value of ATAC-seq in developmental biology?

It identifies open chromatin

It identifies all genes that are being turned off

It maps all methylation sites across the genome

It identifies all RNAs expressed in a tissue

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Consider the family pedigree below, in which a monogenic autosomal congenital abnormality is denoted by shaded squares/circles.

Based on the pedigree shown, what term best describes the abnormality?

Y chromosome-linked

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What modification of the HTT gene would be needed to model Huntington’s disease in neuronal stem cells derived from an unaffected human?

Addition of an additional 5’ exon

Addition of many CAG sequences

A reduction in trinucleotide repeats

Introduction of a STOP codon

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A gene in the mouse embryo is maternally imprinted. What does this mean?

Only the copy inherited from the father is expressed.

The gene is only passed down through females.

The gene is only expressed when inherited from the mother.

The gene is expressed in male embryos but not in females.

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A gene is being actively expressed. Under what conditions would this most typically occur?

Histone deacetylation

Removal of histones.

Histone acetylation.

CpG DNA methylation

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What is the role of TGFβ3 in palate formation?

It induces formation of the primary palate

downward growth of palatal shelves

midline fusion of secondary palate

It induced cleft palate

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What is the cellular basis of Treacher-Collins syndrome?

Reduced production of neural crest cells.

Reduced apoptosis of neural crest cell progenitors.

Ectopic migration of neural crest cells into the second branchial arch.

Failure of neural tube closure.

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