A 65-year-old man with chronic myeloid leukemia on imatinib develops severe muscle pain after starting simvastatin for hyperlipidemia. What is the most likely explanation for this adverse effect?

A patient with Philadelphia chromosome-positive chronic myelogenous leukemia (CML) is started on a tyrosine kinase inhibitor. Which drug is most appropriate?

Which drug is associated with pulmonary fibrosis as a notable adverse effect?

A patient develops hemorrhagic cystitis after chemotherapy. Which drug likely caused this adverse effect?

Which drug combination is most appropriate for HER2-positive metastatic breast cancer?

A 55-year-old man with chronic kidney disease is prescribed gentamicin for a severe infection. What is the most important reason to adjust the dose in this patient?

A 6-year-old child is treated with amoxicillin for otitis media. After 48 hours, the fever persists. Culture reveals Haemophilus influenzae resistant to ampicillin but sensitive to amoxicillin-clavulanate. What is the most likely mechanism of resistance?

A 25-year-old woman presents with dysuria and increased urinary frequency. Urinalysis confirms a urinary tract infection. She has no allergies and is otherwise healthy. Which antibiotic is most appropriate as first-line therapy?

Which antibiotic is known to be a potent inducer of hepatic drug-metabolizing enzymes?

Which of the following antibiotics is most likely to cause a disulfiram-like reaction with alcohol?