Which cells will be missing in a patient with congenital agenesis of the displayed organ?

A 68-year-old patient presents to a

dermatologist. He is bothered by a small, light-coloured growth near his left

eye. The dermatologist is rightly concerned that it is a basal cell carcinoma,

which is confirmed by the pathologist after the tumour is removed. Basal cell

carcinoma is a skin tumour arising from keratinocytes of the stratum basale.

This tumor combines some features of both malignant and benign tumours. Which

statement about normal cells of stratum basale is true?

A 63-year-old female patient comes to the doctor

because of worsening fatigue, and she has recently lost a lot of weight unintentionally.

She has occasional pain in her left lower back and often feels full after

eating. During physical examination, the woman is subfebrile and relatively large

splenomegaly (enlarged spleen) is present. The blood count shows marked

leukocytosis with a left shift in neutrophils, eosinophilia, basophilia as

well as thrombocytopenia and anemia. Cytogenetic examination of the bone marrow

aspirate demonstrates the presence of the Philadelphia chromosome and further

examination confirms the diagnosis of chronic myeloid leukemia, which in this

patient is associated with hypersplenism, i.e., excessive function of the

spleen, which increasingly destroys red blood cells. In which part of the

spleen does this red blood cell destruction take place?

The figure shows normal cortical (cerebral) tissue, which was obtained from an autopsy. Which of the following cortical areas is most likely to be the source of the tissue? We tell you that this area is dominated by layers with pyramidal cells (laminae pyramidales). 

A

chronic alcoholic presents with truncal instability and an

uncoordinated gait. An MRI confirms alcoholic degeneration of the cerebellar vermis. Which of the following cell types is probably most notably destroyed in this patient?

A 24-year-old man who lives in Africa presents

with muscle weakness in his legs. His physical exam demonstrates muscle

weakness in all limbs, but his legs are most affected. Testing (polymerase

chain reaction, PCR) confirms poliovirus in his cerebrospinal fluid. Poliovirus

mainly affects second motor neurons of the corticospinal tract and, therefore,

will affect cells whose cell bodies are located in which of the following?