Drug metabolites are moved from the capillaries into the filtrate at the distal convoluted tubule.

Proteins are moved from the glomerular capillaries into the filtrate.

Glucose is moved from the filtrate into the blood vessels surrounding the proximal convoluted tubule.

Glucose exits the glomerular capillaries and enters the filtrate.

hydrostatic pressure of the glomerulus

hydrostatic pressure in the glomerular capsule

osmotic pressure in the glomerulus

osmotic pressure in the glomerular capsule

Low systemic blood pressure sensing leads to constriction of the afferent arteriole via the sympathetic nervous system.

High levels of NaCl sensed in the filtrate lead to constriction of the afferent arteriole.

Stretch of the smooth muscle in the afferent arteriole leads to reflex constriction of the afferent arteriole.

juxtamedullary

proximal

cortical

distal

dilates afferent arteriole to increase GFR

constricts afferent arteriole to decrease GFR

constricts afferent arteriole to increase GFR

dilates afferent arteriole to decrease GFR

This will have no effect on GFR.

This will cause a decrease in GFR.

This will cause an increase in GFR.

efferent arteriole

afferent arteriole

capillaries

venule

D

A

C

B