RER is involved in production of proteins and SER in production of ATP

RER is involved with protein synthesis and SER with the production of products for secretion from the cell

RER is linked to the nucleus and the Golgi apparatus and the SER is not.

RER is spotted with ribosomes and SER is smooth because of the absence of ribosomes.

RER uses enzymes for breakdown of waste material and SER uses enzymes and O2