A
patient in intensive care has a bloodstream infection caused by a carbapenem-resistant
Acinetobacter baumannii s train. Initial
treatment uses colistin, a polymyxin antibiotic. During treatment, colistin
resistance evolves. What is the most likely mechanism of colistin resistance?

Question

A
patient in intensive care has a bloodstream infection caused by a carbapenem-resistant
 Acinetobacter baumannii s train.  Initial
treatment uses colistin, a polymyxin antibiotic. During treatment, colistin
resistance evolves. What is the most likely mechanism of colistin resistance?

Accepted Answer

Mutation
in  pmrB  that lead to increased production of a phosphoethanolamine
transferase PmrC

Answer

Mutation
resulting in a missense amino acid substitution in the target RNA polymerase

Answer

Mutation
in the 16S ribosomal RNA gene, leading to an altered ribosomal structure

Answer

Acquisition
of a new beta-lactamase

Crowdly

A patient in intensive care has a bloodstream infection caused by a carbapenem-...

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