In the process of an immune response to a pathogen, both CD4 T cells and CD8 T cells will be activated. In this process:

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The pathogen epitopes that are presented to both the CD4 and CD8 T cells will be identical to enhance effector functions.

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The expansion of both CD4 and CD8 T cells is about equal to provide a targeted and specific response.

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It is the role of the CD4 T cell once activated to then present antigen to naive CD8 T cells to drive activation and the generation of CTLs.

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CD8 T cell expansion will outnumber CD4 T cell expansion due to the effector function of CTLs compared to T helper cells.

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