Which of the following BEST describes the “Loss Of Heterozygosity” (LOH)?

Question

Accepted Answer

When a mutation occurs in the only functional allele of a tumour suppressor gene, rendering it dysfunctional

Answer

When an individual inherits one dysfunctional allele of a proto-oncogene

Answer

When a mutation is acquired in a proto-oncogene, rendering it dysfunctional

Answer

When an individual inherits two dysfunctional alleles of a tumour suppressor gene

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