How do specific gut microbiota-derived metabolites mediate the increase in systemic energy expenditure during Alternate Day Fasting (EODF)?

Question

Answer

Gut
bacteria produce high concentrations of butyrate and propionate, which directly
inhibit white adipose tissue lipolysis to decrease circulating free fatty acid
levels.

Answer

Gut
bacteria convert bile acids into secondary steroids that downregulate
uncoupling protein 1 (UCP1) expression, shunting energy toward muscle glycogen
storage.

Answer

Gut bacteria synthesise acetate and lactate,
which stimulate the browning (beiging) of white adipose tissue to elevate
thermogenesis and reduce overall adiposity.

Answer

Gut
bacteria deplete colonic lactate levels, forcing white adipocytes to undergo
hypertrophy and store excess lipids as monounsaturated triglycerides.

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How do specific gut microbiota-derived metabolites mediate the increase in syste...

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