Bruton’s tyrosine kinase (BTK) is a cytoplasmic signalling
molecule downstream of the B cell receptor. Inhibitors of BTK are clinically
effective in treating certain B cell malignancies by interfering with survival
and growth pathways.

Which physiological function for BTK best
explains why inhibition of this kinase is effective against B cell cancers?

Question

Bruton’s tyrosine kinase (BTK) is a cytoplasmic signalling
molecule downstream of the B cell receptor. Inhibitors of BTK are clinically
effective in treating certain B cell malignancies by interfering with survival
and growth pathways.

Which physiological function for BTK best
explains why inhibition of this kinase is effective against B cell cancers?

Answer

BTK
transmits B cell receptor signals required for B cell growth and survival

Answer

BTK
triggers programmed cell death after antigen encounter

Answer

BTK
blocks B cell development prior to receptor rearrangement

Answer

BTK
prevents antibody secretion in mature plasma cells

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Bruton’s tyrosine kinase (BTK) is a cytoplasmic signalling molecule downstream ...

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