The circadian fluctuation of cellular activities ...

Question

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is tuned and put in register, in the cells of the organism, by the SCN, through overall control of hormonal levels

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is partly regulated by the availability of energetic substrates that influence the activity of AMPK

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is slowed down or accelerated by factors that influence the levels of NAD+ and the activity of casein kinase and of sirtuins

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influences the circadian rhythm of hormonal secretion but may also modify the responsiveness of target cells to hormones

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is an intrinsic feature of cells based on a transcriptional translational feedback loop

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can be modified in its duration by post-transcriptional modifications of the involved proteins

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in influenced by melatonin that may change the lifetime of Per and Cry proteins

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is slowed down or accelerated by phosphorylation, ubiquitination, sumoylation, acetylation, ADP-ribosylation, and O-GlcN-acylation of the various actor proteins

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is governed by melatonin and the light-dark cycle

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is governed by the sleep-wake cycle and feeding and living habits

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The circadian fluctuation of cellular activities ...

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