Both CD28 and CTLA-4 are receptors on T cells that are critical for regulating T cell activity. In which of the following ways does CD28 differ from CTLA-4?

Question

Both CD28 and CTLA-4 are receptors on T cells that are critical for regulating T cell activity.  In which of the following ways does CD28 differ from CTLA-4?

Accepted Answer

CD28 is constitutively expressed on naïve T cells, whereas CTLA-4 is expressed on activated T cells

Answer

CD28 binds B7-1 and B7-2 (CD80 & CD86) with significantly greater affinity than does CTLA-4

Answer

Only CD28 binds the costimulatory ligands B7-1 and B7-2 (CD80 & CD86) expressed on professional antigen-presenting cells

Answer

CD28 is important for delivering “signal 1” for T cell activation, whereas CTLA-4 is important for delivering “signal 2”

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Both CD28 and CTLA-4 are receptors on T cells that are critical for regulating T...

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