If
excess LDL is not cleared efficiently, it accumulates in blood vessels, leading
to the formation of atherosclerotic plaques and increasing the risk of
cardiovascular diseases. But to be cleared up efficiently, the LDL particles
need to be first taken up by the liver cells. The key to understanding how LDL
particles bind to the cell surface and are then taken up into endocytic
vesicles (endosomes) was the discovery of the LDL receptor, which
is a glycoprotein .

Question

If
excess LDL is not cleared efficiently, it accumulates in blood vessels, leading
to the formation of atherosclerotic plaques and increasing the risk of
cardiovascular diseases. But to be cleared up efficiently, the LDL particles
need to be first taken up by the liver cells. The key to understanding how LDL
particles bind to the cell surface and are then taken up into endocytic
vesicles (endosomes) was the discovery of the  LDL receptor,  which
is a glycoprotein .

Answer

The LDL receptor molecule can undergo a conformation change based on the
pH, which in turn affects whether it can bind or release the LDL particle .

Answer

The LDL receptor is present on coated pits which are exposed at the
plasma membrane/surface of the cell.

Answer

At pH 5, the LDL receptor molecule undergoes a conformational change,
which is favorable for it to bind with the LDL particles.

Answer

The lysosome is an organelle that functions as the cell’s digestive
system. In this case, the LDL particle is broken down into amino acids,
cholesterol and fatty acids in the lysosome.

Answer

The LDL particle does not comprise of phospholipid monolayer and apoB
protein (a type of protein).

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If excess LDL is not cleared efficiently, it accumulates in blood vessels, leadi...

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